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KMID : 0857020020170010161
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Kosin Medical Journal
2002 Volume.17 No. 1 p.161 ~ p.165
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A Case of Primary Plasma Cell Leukemia with Atypical Morphology
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Choi Byoung-Joo
Seo Soo-Hong
Chang Seong-Hoon
Kim Yang-Soo
Eo Wan-Kyu
Kim Hyo-Kyoung
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Abstract
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Plasma cell leukemia is a rarely occurring plasma cell disease which is classified to primary plasma cell leukemia and secondary plasma cell leukemia. The clinical manifestations and pathological features are similar to acute leukemia and the prognosis is poor with median survival rate of 4-6 months after diagnosis. When diagnosing plasma cell leukemia, it is often difficult to differentiate plasma cell leukemia from chronic lymphoid leukemia due to the similar cellular morphology of lymphocytes and plasma cells. We report a case of plasma cell leukemia with unusual morphological feature diagnosed by a cell surface marker study. A 81 year old man was presented with renal failure, anemia, thrombocytopenia and atypical lymphoid leukocytosis. Bone marrow examination and peripheral blood smear revealed a large number of pleomorphic cells with some grooving nuclei. Immunophenotype feature of these cells were suggestive of plasma cell origin with positivity for CD38. Furthermore an urine & serum protein electrophoresis showed monoclonal gammopathy of lambda light chain type. The disease initially responded to melphalan and prednisolone, but eventually relapsed.
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KEYWORD
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Plasma cell leukemia, Atypical morphology, CD38
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